Abstract This article intends to resume the question of Jean Beaufret to Martin Heideggerin a letter written in 1946. The Enlightenment project has failed, among the process ofdrafting of human rights, with a Europe in ruins and at the sight human calamity, underthe most sophisticated service of destruction and mass annihilations. For Heidegger,to resume the discussion of humanism in the traditional Western way of thinking is inthis sense, losing the guidance, losing the sense. Heidegger points out the reason: thedependence between the concept of humanism and metaphysics. The concept man,the foundation of modern metaphysics and its political projects is empty. The question,what is humanism? Is the vox clamantis in deserto that opens the consciousness of thecrisis of humanism and general culture. The extension of this negative moment is seen byHeidegger in anthropology, which it seen as another form of humanism that is a sinistertalking bivalent language of metaphysics. Key words: Humanism, metaphysic, anthropology, truth, post-humanism.