Introduction: Infectious Prosthetic Valve Endocarditis (PVE) is a serious and potentially fatal disease. This condition requires a multidisciplinary approach in which multiple factors should be carefully evaluated given its association with a hospital mortality rate ranging from 20-80%; and thus run an individualized treatment approach. Methods: A systematic review of medical records was conducted in the period January 2005 to December 2013; from the database and registration of patients admitted to the Fundacion Cardioinfantil - IC who underwent the diagnosis of PVE according to the modified Duke diagnostic criteria and protocol of the institution. Epidemiological, demographic, treatments received and outcomes found using summary measures, the corresponding measure of dispersion and absolute and relative frequencies depending on the nature of the variable: a descriptive analysis of the variables of patients were executed. The analysis of the main objective for differences between the patients who died and survivors cases was developed. Results: 60 cases of PVE were identified in the related period. The average age of all cases was 54.1 years and 64 years for the group of death. The presence of neoplasia was the strongest factor associated with mortality and the presence of Heart Failure OR 5.2 (95% CI 0.4 to 66.4), identifying fistula echocardiographic (p = 0.015) and isolation of Staphylococcus Aureus (p = 0.03). The increased hematocrit to 33% OR 0.65 (95% CI 0.4 to 1.0) was a protective factor for mortality. Conclusion: The EVP is associated with increased hospital mortality where factors such as Heart Failure, neoplasia, anemia, isolation of S. aureus and echocardiographic finding of fistula were identified as independent risk factors for mortality.