This study focuses on the preparation of tapioca starch biodegradable polymer, processed by blends of starch modified with glycerine and water as plasticizers, by using roll mill and a single–screw extruder in the process. During extrusion, there is a series of variables to control namely: the barrel temperature profile, screw torque and screw rotation speed. Tensile test, Differential Scanning Calorimetric (DSC), Thermogravimetric Analysis (TGA), Fourier Transformer Infrared Spectroscopy (FTIR) and morphology were used in the process.