Peptide synthesis has become as the most powerful tool to obtain synthetic vaccines as well as new peptide-based drugs against infectious diseases such as Malaria and AIDS. During the last three decades an increasing number of synthetic peptide-based drugs have been offered in the market, but the most remarkable finding in this field has been the design and synthesis of the SPf-66 malaria vaccine which still remains as the most promising agent against human malaria. Based on this knowledge, the future of synthetic peptides will permit the finding and discovery of new and more potent vaccines to prevent human affecting diseases. This review describes the importance of having new methods to afford synthetic peptides as well as its implications on scientific research.