Mine tailings cause several environmental impacts, due to high and progressive mineral exploitation, as well as waste management considerations. Alkaline activation to manufacture building materials using waste as cementitious materials has been a used method. In this article, concretes with alkali-activated mine tailings have been studied. Coal mine tailings (sandy-RC and clay-RCd) and vein gold mine tailings (flotation tails-CF) were activated by a mixture of NaOH and Na2SiO3 solution. Alkaline activated mortars, using original granulometry tailing and / or milled residue and partial substitutions for type I Portland cement of 10 and 20% as co-binder for milled mine tailings as precursors were manufactured initially. The milled CF with 20% partial substitution by cement did not reach the resistance of the reference mortar and concrete, therefore, two more conditions were prepared (best compressive strength after 28 days of setting). The mix design of the milled CF with 30% cement surpassed the compressive strength of the reference mortar. Hence, mix design was used to manufacture alkaline activated concrete, which also surpassed the strength of the reference concrete after 28 days of setting with 25.3 MPa and with a percentage of reduction emissions of 29.04%.