ammography is low. Nowadays, tomosynthesis is an additional tool available besides mammography, however there is limited national evidence regarding the diagnostic consistency between tomosynthesis and breast biopsy. Objectives: To estimate the consistency between tomosynthesis and breast biopsy in adult women with suspicious cancer lesions. Methodology: Retrospective, diagnostic concordance trial. Results: The principal group with biopsy-confirmed suspicious malignant breast lesions was between 50 and 60 years of age. The most frequent diagnoses with tomosynthesis were: nodules (27.5%) and microcalcifications (21.9%). With biopsy, 21.25% of the women had a diagnosis of infiltrating ductal carcinoma. BI-RADS 4 category was reported in 86% of the cases. The Kappa coefficient was of 0.406 (p<0.001) with tomosynthesis and biopsy in patients with suspicious lesions of the breast. The sensitivity and specificity was: 84% (95% CI 71.5% - 91.7%) and 63.6% (95% CI 54.3% - 72.0%) with positive and negative predictive values of 51.2% (95% CI 40.6% - 61.7%) and 89.7% (95% CI 81.0% - 94.7%) respectively. The mean radiation dose used was 7.9 mGy. Conclusions: There is moderate consistency betweentomosynthesis and the histopathological study of the breast. Tomosynthesis shows good sensitivity and acceptable specificity in the evaluation of suspicious breast lesions.