To establish the relationship between health related quality of life (HRQoL), sociodemographic and clinical variables in adults with pulmonary hypertension (PH) of any cause from Manizales. Methodology: Correlational descriptive study between HRQoL, sociodemographic and clinical variables. We evaluated 94 people with HP who met the inclusion criteria, we applied questionnaire HRQoL SF-36v2. To analyze the information we established difference in means and correlation coefficients when statically significant differences were found (p<0,05). Results: For sociodemographic variables, we found statically significant differences with current occupation in (p=0,016) and socioeconomic stratum (p=0,015) with regard to total physical and mental health scores respectively; the age range, educational level and social security affiliation variables showed statically significant differences (p<0,05) with the dimensions of physical function, physical role, body pain and general health. In relation to clinical variables, we found statically significant differences with diagnostic time in years (p=0,013), functional class NYHA/OMS (p=0,025), use of domiciliary oxygen (p=0,022), use of anticoagulants (p=0,023) and pulmonary morbidity (p=0,026) with total scores of physical and mental health. With the classification of PH, functional class NYHA/OMS, use of anticoagulants in renal and rheumatologic morbidity showed statically significant differences (p<0,05) with different dimensions of the HRQoL; the correlation degree was variable in each of the relations. Conclusion: There are different degrees of correlation between sociodemographic and clinical variables with total scores and CVRS dimensions evaluated with the SF-36 in people with pulmonary hypertension in Manizales.