Introduction: although the viral infections of the lower respiratory tract (LRTI) represent a public health problem in tropical, low to moderate income countries (LMIC) and there is increasing evidence of a relationship with meteorological factors, few studies are carried out in those countries. Methods: a cross-section trial identified which of the major meteorological factors (temperature, relative humidity, rainfall, wind velocity and solar radiation) are predictors of the RSV activity in a population of patients hospitalized due to viral LRTI within a 5-year period, from January 2009 through December 2013. Results: out of 4,559 children included in the trial in total (mean age 9.2 ±8.5 months), 2,953 (64.8%) presented RSV infection in the trimester from March through May. The multivariate analysis after controlling for relative humidity, wind velocity and solar radiation (IRR 2.36, 95% CI 1.33 - 4.18, p=0.003), and rainfall (IRR 1.01, 95% CI 1.00 - 1.02, p=0.044) were independently associated with the monthly number of cases of RSV infection. Conclusions: in Bogota, a moderate altitude city localized slightly north of the Equator, the RSV is active throughout the year, with a peak in May, Bogota’s rainy season. Additionally, rainfall and temperature are the two key meteorological parameters showing an independent association with the RSV activity in RSV-hospitalized children in the city.