Introduction: perinatal mortality is the result of the maternal health status, the interaction of bio-psychosocial factors during pregnancy, and the quality characteristics of the healthcare provided to both the mother and the fetus. Objective: to analyze the perinatal mortality in the 2012 and 2013 cohorts at the Colombia University Clinic. Methodology: descriptive, retrospective study with data collected by the perinatal mortality surveillance sub-system of the Colombia University Clinic. Provide complementary information based on the review of medical records and death certificates. The analysis of the data was done using the BABIES Matrix and the Delays Model. Results: in 2012 there were 72 perinatal death events of which 77.7% were associated with maternal risk factors, with pre-eclampsia as the major morbidity associated. The rate for that year was 23.6 per 1,000 life births. In 2013 there were 68 events, 64.1% of which were associated with maternal health risks. Based on the Delays Model, Delays I, II, and III play a relevant role in both years. Conclusions: the perinatal mortality at the Colombia University Clinic has a behavior similar to that described in the literature. There is a need to develop actions leading to an improved knowledge about the bio-psychosocial risks of pregnant women, ensuring the respect for sexual and reproductive human rights, and the knowledge of warning signs and signals, in addition to developing skilled human resources.