To determine the effect of an intervention program based on motor relearning on the level of health-related quality of life in adults with hemiparesis.Materials and Methods: A clinical trial of quasi-experimental scope was carried out under the empirical-analytical approach in which 69 people with hemiparesis of different etiologies were intervened in the cities of Bogota, Medellin, Cali, Barranquilla, Manizales, Pereira, Neiva, Popayan and Tunja, among others, of which 34 were part of the control group who received a conventional therapy program and 35 people were part of the experimental group who received a motor relearning program for six weeks, three times per week, in order to determine its effect on the level of health-related quality of life (HRQOL), which was evaluated with the WHOQOL-BREF instrument before and after the intervention. The information was processed using the statistical program SPSS version 22.0 (Statistical Package for the Social Science).Results: After intervening with a conventional program and a motor relearning program, neither the control nor the experimental group found statistically significant differences between the post-test and the pre-test in the global assessment of HRQOL (Global HRQoL), despite the marginal significance observed in the experimental group in which an average improvement of three points was obtained (p = 0.056), however, significant differences were found in the physical health dimension of the experimental group and in the overall HRQL dimension of both groups (p <0.05), in which the experimental group perceived an average improvement of 8 points in contrast to 6 points of the control group.Conclusions: Although there are no statistically significant differences in terms of HRQOL results between the application of a motor relearning program vs conventional therapy applied to people with hemiparesis, it is important to keep in mind that both motor relearning programs and conventional therapy have positive effects in different domains of quality of life.