A descriptive retrospective cohort study was carried out, having as the unit of analysis the clinical records of 108 patients with histopathological diagnosis of colon cancer, between January 2003 and December 2010, from an Oncological Service Provider Institution of the city of Manizales . The objective was to calculate survival at one, five and ten years, and to identify the relationship between the person, socioeconomic and disease variables with survival. Survival analysis was calculated using the Kaplan-Meier method; the comparison according to variable using Log-Rank and the Cox proportional hazards method was used for probabilistic modeling. The mean age of diagnosis was 61 ± 11 years. Overall survival at 5 years was 37%, with a mean of 53.79 months (95% CI: 43.63-63.91), clinical stage IIA stood out with 85.9 months of survival, along with stages I and IIIB (50.4 and 50.1 months). respectively). Survival was higher for women (43.3% vs. 30.6%) and the main prognostic factor was the presence of metastasis (RR 1.8, 95% CI: 1.28-2.56). Therefore, it is concluded that survival in colon cancer in early stages is higher, and according to sex, women live longer; being the presence of metastasis the main prognostic factor of the disease for both groups.