The Covid-19 disease was declared a pandemic in March 2020. Its clinical manifestationsare varied: from asymptomatic patients to severe respiratory disease and multiorganicfailure, which can lead to death, those patients who worsen require Invasivemanagement in the intensive care unit, moving to two stages of the natural evolutionof the disease, either survival or non-survival, for those who manage to get out earlywith multidisciplinary support, a considerable number of multisystemic sequelae aregenerated in the long term . During this systematic review of the literature, the clinicalcomponents at the cardiopulmonary, musculoskeletal and mental levels will be exposed,as well as the interdisciplinary role in the rehabilitative management of the post-COVID-19 patient.When a patient leaves hospitalization for this casuistry, he believes that he is fullyrecovered, and that is where it becomes a challenge of joint medical action betweenthe Internist, the Anesthesiologist, the Physiatrist, the psychiatrist and the orthopedist,as treating specialties. direct during the process of pathological progression, todemonstrate the direction in the integral rehabilitation that should be protocolized inthis type of patients.