The traditional knowledge of rural communities that inhabit Andean regions is very important for biodiversity conservation and local development; nevertheless ethnobotanical studies in andean mountains are scarce compared to those carried out at tropical lowlands. The present work aims to characterize the local use of plants in the rural community of vereda Verjon Bajo, located within the “Reserva Forestal de los Cerros Orientales” at Bogota City. The community of the study area is composed mainly of peasants with a farming tradition and people from Bogota city who have settled in luxurious residencies in the area. The study follows the key-informant interviewing methodology, information was collected about the common names and traditional uses of wild and cultivated plants. A total of 109 useful plants (52 families) were recorded. Most reported plant families were Asteraceae (12 spp.), Rosaceae (10), Lamiaceae (9), Solanaceae (6) and Ericaceae (5). Most plants are used as medicine and food (28 spp.), ornamental uses (22 spp.), in living fences (17 spp.) and for their wood (13 spp.). Most of these plants (61%) are cultivated at home gardens. This rural community has an important traditional knowledge about the use of plants, and maintains its agricultural heritage. Home gardens might be important for the sustainable development of this region given they are the principal space of convergence of traditional knowledge of useful plants.