Femicide is one of the leading causes of death for women in Latin America. Despite the variability of cases between some countries, this phenomenon represents a shocking problem that affects the guarantees of the right to gender equality, one of the negative impacts that COVID 19 produced was precisely the increase in cases of feminicides worldwide, therefore, this article Biological, Genetic, Social and Psychological Aspect of Femicide aims to analyze the Biological, Genetic, Social and Psychological Aspects of Feminicides exposed in times of COVID-19, by means of a qualitative methodology of literary review. The results indicate that aggressiveness and power asymmetries increase in reduced environments and in the face of the limitations perceived by the individual, such as socioeconomic problems, loss of employment, higher levels of anxiety and depression, which together with other aspects produce aggressive behaviors.