Objective: To describe the incidence of acute flaccid paralysis (AFP) and potential relationship with acute flaccid myelitis (AFM) in Latin America and the Caribbean over the last 10 years. Background: AFP is a sudden onset of paralysis/weakness in any limb. Surveillance for AFP in Latin America was established as a public health effort for targeting eradication of poliomyelitis. However, other causes of AFP like AFM are frequently not investigated. Identification of features to distinguish AFM from other causes may help guide appropriate diagnosis and treatment of AFP leading to better outcomes. Design/Methods: We analyzed annual reports from Pan American Health Organization (PAHO) from 2008 to 2018, to investigate epidemiologic data about AFP and its characteristics in 23 countries in the Americas. We included and analyzed data from countries with an incidence rate >1 (>1 per 100,000 children Results: 11 countries were included in the analysis (Bolivia, Colombia, Costa Rica, Honduras, Nicaragua, Panama, El Salvador, Mexico, Argentina, Chile and Paraguay). We found two periods, 2011 and 2016, with peaks of incidence of 1,8 and 1,9 per 100.000 children respectively, which were markedly higher than the baseline trend. The country with the highest number of cases of PFA was Mexico (5835), although the highest incidence rate of PFA was El Salvador (2.35). The average number of cases increased through the years, 995 cases with a rate of 1,473 were reported in 2008, and 1239 cases with a rate of 1,614 were reported in 2018. The number of suspected cases of polio was high, but there were few confirmed cases of polio by laboratory. Conclusions: The increasing incidence of AFP in some countries in the Americas requires special attention to improve the diagnosis and management of non-polio related flaccid myelitis such as AFM. Disclosure: Dr. Chen has nothing to disclose. Dr. Garcia-Dominguez has received research support from Bart McLean Fund for Neuroimmunology Research. Dr. Pardo-Villamizar has received research support from McLean’s foundation.