Objective: To characterize epidemiologically and clinically patients diagnosed with liver cirrhosis in the Colombian Caribbean region, receiving care in the Gastroenterology and Hepatology Unit of the Clinica General del Norte, from January 2012 to March 2017. Materials and methods: Descriptive cross-sectional and retrospective study; sample for the convenience of 284 patients with diagnosis of hepatic cirrhosis, whether clinical, laboratory, imaging or histopathological. The information was tabulated in Epi-Info 7.0 program, descriptive statistical parameters were evaluated. Results: 70.4% of the patients came from the Atlantico department, main reason for consultation was altered liver imaging in imaging studies 36.2%; the most frequent etiology was C virus with 28.5%, 66.2% had well-compensated disease (CHILD-A). Conclusions: The etiology of hepatitis C virus is the most prevalent in the local environment, followed by non-alcoholic fatty liver, autoimmune hepatitis, primary biliary cirrhosis, alcohol, viral hepatitis B and other etiologies.