Introduction. The performance of a digestive ostomy must cause alterations in the dimensions of the being such as physical, mental, social and cultural, which generates compromises in the quality of life. Objective. To evaluate the impact on the quality of life of the person with an ostomy condition in the city of Manizales. Methodology. Study developed through a quantitative phase with a descriptive observational design using the Montreaux questionnaire for the assessment of quality of life and a qualitative, phenomenological phase carried out through semi-structured interviews in which 16 people with ostomized conditions participated. Results. Average age 56 years, 75% of them belonged to low socioeconomic status, 50% had primary education and 50% had secondary education. 75% belonged to the contributory health scheme. The quantitative results showed a quality of life index of 44.5%; The aspect with the highest percentage in quality of life was the fact of not having social concerns, 73%, on the contrary, the lowest percentage was obtained in the aspect related to sexual activity, 25%. A self-sufficiency percentage of 80% was identified, but a negative adaptation in 50% of the cases. The qualitative results showed seven categories that describe the aspects that alter the quality of life and self-care: feeling of disability, job loss, alteration of body image, coping according to duration and position of the ostomy, projection of the future, social isolation and alteration of sexuality. Conclusion. The quality of life index was low and the categories found confirm the aspects of daily life of people with an ostomy condition and the need to provide comprehensive care where the role of nursing is widely visible.