Introduction: Cardio-respiratory diseases are the largest causes of death and disability in the world. Long-term oxygen therapy in severe chronic hypoxemic improves survival, however, it is one expensive therapy and exert a large burden on the health systems. In Colombia the cost of this therapy are not quantified. Objective: Describe the costs of the administering long-term oxygen in a group of patients enrolled in a program of domiciliary oxygen in Pereira, Colombia. Materials and methods: Study prospective descriptive. We describe the clinical characteristics and calculated the costs of administration of: oxygen, medication, vaccination, nebulization and hospital care. Results: A total of 215 patients were