Spanish Abstract: Los analisis del ecosistema emprendedor colombiano han identificado oportunidades alrededor de la economia naranja. Adicionalmente, su articulacion con la educacion superior tiene un gran potencial para contribuir en la formacion de profesionales generadores de empleo, que contribuyan al desarrollo y bienestar de poblaciones vulnerables. El articulo presenta los primeros resultados de una investigacion orientada a disenar un modelo de internacionalizacion de economia naranja entre dos ciudades latinoamericanas: Bogota (Colombia) y Zacatecas (Mexico). Para ello, explora diferentes vinculos entre el emprendimiento y la academia, asi como la reciente incorporacion de la economia naranja, no solo como una alternativa de generacion de ingresos, sino que anade un componente de creatividad. English Abstract: Analyzes of the Colombian entrepreneurial ecosystem have identified opportunities around the Orange Economy. Additionally, its articulation with higher education has great potential to contribute to the training of professionals that generate employment, which contribute to the development and well-being of vulnerable populations. The article presents the first results of a research aimed at designing an internationalization model of the Orange Economy between two Latin American cities: Bogota (Colombia) and Zacatecas (Mexico). To do this, it explores different links between entrepreneurship and the academy, as well as the recent incorporation of the Orange Economy, not only as an alternative for generating income, but also adding a component of creativity.