The objective of the present work was to evaluate the efficacy of the compound Hemoveex® (isometamidium chloride 2,4% and ivermectin 2,0%) of Reveex, a Venezuelan laboratory, on the control of mixed infections of Trypanosoma vivax and gastrointestinal nematodes in bovine. Sixteen one year old heifers, assigned to two experimental groups (intramuscular (IM) and subcutaneous (SC)), were treated each with Hemoveex® at the dose of 1 mililiter (mL) /50 kg of body weight (BW); previously, all 16 heifers had been inoculated with 5 mL each of bovine blood showing 4 flagellates/100X microscopic field of Trypanosoma vivax initially obtained from a cow in Puerto Berrio, Antioquia, Colombia and further multiplied in a calf at the Jaime Isaza Polytechnic of Marinilla, Antioquia. The assignment to either group, was made on the basis of the “strongylid” nematode type egg per gram (epg) of faeces, using the McMaster technique. From day (d) 1 after treatment to d 63, when observations finished, no trypanosomes were seen in any of the sixteen heifers. As for the control of gastrointestinal nematodes, the association showed efficacies of 36, 12, 24 and 84%, on d 7, 28 and 42, and 63 posttreatment (PT), respectively, when applied by the IM route and of 47.8, 39.1 and 78.3%, on d 21, 28 and 63 PT, respectively, when administered (SC). Isometamidium + ivermectin was highly efficacious against Trypanosoma vivax, given either IM or SC presented a satisfactory anthelmintic efficacy only by d 63 PT.