The present investigation seeks to examine the transformation and construction of the concept or political myth of “American exceptionalism as a socio-cultural product of the idiosyncrasy and from which anti-terrorism strategies and policies have been developed and implemented in the region of the Middle East through the declaration of an official state of War on Terror since 2001. The main argument is based on affirming that the exercise of creation and recreation of the enemy has always been a part of the strategic and discursive task of the US government, and nowadays, in the midst of the XXI Century, the transcendence of the terrorist phenomenon has intensified because this actor continues posing enormoues challenges to US national security and global stability in a major scale, and it is constituted as a long-range decentralized organization with modalities of action that escape the control of States, without predictability in its attacks, without an accurate location regarding its headquarters of operation and without a distinctive badge of combat internationally recognized by law. The cause of the struggle and its essence has remained intact, which has forced powers like the United States to resort to unconventional strategies of struggle (soft power, promotion of Western institutions, economic reinforcements, multilateral cooperation) to achieve an advance of the Arab-Muslim world and reinforce the impacts of containment of the threat. The research aims to identify and characterize the successive security strategies from the constructivist perspective to introduce the reader into the motivations and interests that were germinating within the international system and which under the worldview forced it to act. Finally, the research concludes by attributing a special character to this concept of American exceptionalism (fourth generation), which has been transformed over the years and thus generate a new concept and an academic contribution to the International Relations discipline.