The present work proposes a reflection on the Italian companies and businessmen of the central region of Argentina, since it is a subject less studied by the specialised literature. The lack is more noticeable if one tries to make a comparative study of two of the provinces ot fhe Country, as it is this case. However, a series of socio-political, economic and demographic factors give relevance to the subject in question. In the first place we must define the term “Region Centro” (Central Region), implemented at the end of the 20th century to designate an area composed by the provinces of Cordoba, Santa Fe and Entre Rios, which presents a certain homogeneity in diverse factors, such as climate, soil characteristics, transport infrastructure, among others, which makes its use here operative. El presente trabajo se propone reflexionar sobre las empresas y los empresarios italianos de la region central de la Argentina, en tanto es un tema menos estudiado por la literatura especializada. La carencia es mas notable si se pretende hacer un estudio comparativo de dos de las provincias que la componen, como es este caso. Sin embargo una serie de factores sociopoliticos, economicos y demograficos otorga pertinencia al tema en cuestion. En primer lugar debemos definir el termino Region Centro, implementado a finales del siglo XX para designar un area compuesta por las provincias de Cordoba, Santa Fe y Entre Rios, que presenta una cierta homogeneidad en diversos factores, tales como el clima, las caracteristicas del suelo, la infraestructura de transporte, entre otros, que hacen operativo su uso aqui.