SUMMARY Introduction: In Colombia, the first cause of disease and death due to childhood cancer is given by acute leukemias, with 539 new cases and 295 deaths each year, followed by malignant tumors of the central nervous system (126 new cases per year with 90 deaths) and non-Hodking lymphomas with 126 new cases presented per year and 51 deaths in the same period(1), because they are minors with a complex pathology they require the permanent accompaniment and care of an adult who will fulfill caregiver duties. At the Fundacion Hospital Pediatrico la Misericordia there is no evidence regarding the characterization of caregivers of pediatric oncology patients. (2) Objective: To determine the sociodemographic profile, competencies and overload of caregivers of pediatric oncology patients at the Fundacion Hospital Pediatrico de la Misericordia, second semester of 2020. Materials and Methods: Cross-sectional and descriptive study, the study population consisted of 112 main caregivers of children diagnosed with oncological disease, hospitalized during the second period of 2020 and who met the inclusion criteria. The instruments applied were the characterization form of the dyad - person with chronic disease GCPC-UN-D, caregiving competence version 5.26 and caregiver abbreviated version and the Zarit caregiver overload assessment scale version 5.26; descriptive statistics were used for the analysis using the SPSS version 22 statistical package. Results: The mean age of the children was 8 years (ds. 5.05), most of the children have a diagnosis of leukemia followed by patients with central nervous system tumors and lymphomas, 82.1% of the children are cared for by their mothers, followed by fathers and siblings; a little more than 50% of the caregivers come from Bogota and Cundinamarca, most are living in Bogota in sectors of stratum 1 to 3; Most of the caregivers live in a free union and report household activities as their main occupation; a high level of competence was found among the caregivers for the attention and care of the children at home; 21.4% of the caregivers report a slight overload and 8% report an intense overload. Conclusions: most of the caregivers are women and mothers who dedicate more than 12 hours to the care of children. The caregivers report high caregiving competence and low caregiver overload; it is necessary for the nursing professional to identify these aspects and plan actions to reinforce caregiving competence and decrease the risks of overload.