The Clinical History has some special characteristics that require different management from the point of view of computer security. Given the above conditions to maintain its integrity, in addition for complying with the regulations of each country, it is convenient to modify the traditional form by means of manuscripts, to the use of information technologies. With this evolution, the incidents of cybersecurity in a sector as critical as this one, have a great impact on society, such as information on history. Damage to information or alteration of patient data. Applying Colombian Resolution 1995 of 1999 [1], it follows that patient information must correspond chronologically, in the same way as medical acts, procedures performed by the doctor's team or any intervention in their care, throughout the given the facts, health systems are becoming increasingly vulnerable to computer security, automation, information technology, information and connection with patients; At the same time, the inclusion of security in health information systems is not a priority. The result of this research is a comprehensive methodology that allows accessibility in the system, the integrity of the data, the possibility of carrying out an analysis in the case of vulnerability, the same time in which mitigation of the causes is being achieved, generating alerts, electronic data in clinics cannot be protected