The cape gooseberry (Physalis peruviana) is a fruit species that has become very important in Colombia because of its potential for export as fresh fruit. The foreign exchange generated represents several million dollars a year, placing it in second place after bananas. In addition, it is also considered an exotic tropical fruit which generates interest in the market, this economic importance has allowed a greater focus on the crop, however one of the most notorious problems is related to diseases transmitted by phytopathogenic fungi, especially Fusarium oxysporum, which not only affects many investigations but also the economy and production of the country. F. oxysporum is a difficult pathogen to control, because it has the ability to spread through fragments of diseased plants, infected plant material and movement of soil infested with chlamydospores, which can survive for more than 10 years, such characteristics have allowed that the controls of this fungus are minimal and at the same time dangerous to human health, For this reason, this study seeks to incorporate the use of biologically active molecules such as chalcones, amino acids such as tryptophan, putting into practice the use of chemical synthesis to enhance the antifungal activity of such molecules against Fusarium oxysporum and at the same time reduce the incidence of this phytopathogen and be environmentally friendly