The high-flow nasal cannula is a respiratory support modality used for some years in neonatal units, for the treatment of pathologies such as apneas or as an adjunct in the withdrawal of invasive mechanical ventilation. This system provides a mixture of gases (oxygen - air), and delivers an Inspired Fraction of humid and warm Oxygen, favoring the reduction of pathologies derived from oxygen such as retinopathy of prematurity and bronchopulmonary dysplasia. The present study aims to review the relationship between the use of a high-flow cannula and the regression of retinopathy of prematurity. Methodology: Specialized databases such as Lilac, Pubmed and Science Direct were consulted, the information search was carried out between the years 2014 to 2019, using MesH terms in English and Spanish languages. Results: The first search was of 465 articles, later those that met the inclusion criteria for this study were selected, leaving a total of 22 articles, then the contribution with the topic was reviewed and classified into: retinopathy of prematurity, oxygen neonatal and high-flow nasal cannula. Conclusions: The use of the high-flow nasal cannula system with inspired oxygen fractions lower than 0.25 in premature patients with a diagnosis of retinopathy of prematurity, evidenced an important regression of retinopathy by up to 80% in its early phase, however , future research is suggested to support its use, since little information has been published on the subject.