The bioeconomy has gained attention in policy and academia scenarios as well as the need for strategies to foster the transition toward a more sustainable economic model. This paper provides evidence of the contribution of the bioeconomy to the value added and employment in Colombia and Antioquia, one of its regions. Since knowledge and scientific research are determinant factors for the bioeconomy strategies, relevant indicators of human capital and bioeconomy-related research capacities are studied for the case of Antioquia. The results show that bioeconomy in Colombia represents around 11% of the total value added and 21% of the national employment, which provides a baseline to building a monitoring strategy of the bioeconomy in Colombia and its regions.