In Colombia, as a public policy, all people, regardless of their income level or ability to pay, have full access to health services, to guarantee coverage and provision of health services, the municipal government of Ibague Tolima, it has consolidated a single care front called the Ibague USI Health Unit; the objective of this document is to calculate the incidence of the business fabric against the possibilities of missionary strengthening in the USI; The objective of this document is to calculate the incidence of the business fabric against the possibilities of missionary strengthening in the USI. To meet the objective, a quantitative methodological design, of a case study type, is used for the financial sustainability figures, where the liability account and the income items for the provision of services in the subsidized regime are subsumed, in the processing data is made using a simple linear regression. Projecting the data for the current term with the unemployment rate and business informality in the region. The results show an increasing trend in affiliates to the subsidized regime, therefore a healthcare service system, with low reaction capacity due to the financial constraint in the USI, the above, motivated by a larger number of subsidiaries. With these results, it can be concluded that the services offered by the USI of Ibague Tolima will remain static or may deteriorate in quality, due to low financial sustainability and a business fabric concentrated in micro and small companies, where the proportion of employees or entrepreneurs is lower who do not make contributions to the contributory health system.