Background: The World Health Organization (WHO) has recently launched the strategy towards the elimination of cervical cancer, including as main targets to reach high screening coverage rates with highly sensitive tests and to treat women with cervical lesions. The region of Latin America has the second-highest cervical cancer incidence and mortality rates worldwide, with previous evidence of the influence of socioeconomic factors as key determinants to the development and progression of the disease; previous studies have described the advancement of screening programs and coverage rates in the region, however, information regarding the current recommendations is scarce. Objective: To describe the current cervical cancer screening recommendations in Latin American countries, their implementation context, as well as to define strategies for the follow-up and evaluation of screening programs. Methodology: A mixed study was carried out, conducting a documentary investigation regarding the current official recommendations for cervical cancer screening, its implementation context, and the screening coverage data from 19 Latin American countries. Additionally, an expert consensus was conducted, using the Delphi method, with the aim of identifying a set of indicators for the follow-up of cervical cancer screening programs, applied to the regional context. A descriptive and bivariate statistical analysis was carried out to comprehend the correlation between some contextual variables and the screening coverage, the cervical cancer incidence and mortality. Results: Latin America is a region with a wide variability in the organization of cervical cancer screening programs. Countries in the region report relevant differences related to the programs' implementation context, health system types, as well as the cervical cancer incidence and mortality rates. In most countries, there was a decrease in mortality rates during the last 15 years. Cervical cancer screening recommendations varied significantly between countries, with different target populations (starting age: 20-35 years old; termination age: 54-70 years old), employing different screening intervals (range: 2-5 years), and featuring the concurrent use of different screening tests (supplementary or indistinct use). During the last decade, more than half of the countries in the region had updated their recommendations; with an evident evolution towards the introduction of the HPV detection test and screen and treat strategies; 11 countries have introduced HPV testing as part of their recommendations, with cytology as the main triage test. Variability in the screening coverage data from demographic surveys was evident among countries. We collected cervical cytology coverage rates from 17 countries (women 15 to 59 years), with a median of 70,9%, with rates between 38,7% (Mexico) and 96% (Venezuela); only Mexico reported data including the HPV detection test coverage. Furthermore, there was a significant correlation between some sociodemographic factors such as urbanization level, income level, inequality-adjusted human development index as well as health expenditure per capita, related to cervical cancer incidence rates. Cervical cancer mortality rates showed to be correlated with the same contextual variables as the incidence rates, and additionally, showed to be correlated with the universal health coverage index. There was a significant difference in the median mortality rates from countries with more or less screening coverage with cytology, with lower mortality rates in countries with higher screening coverage rates. Finally, as a result of the consensus carried out with 13 regional experts, we conformed a basic set of 9 screening programs' follow up indicators and a complementary set of 5 indicators related to the screening intensity, the follow up of positive women, as well as result, system capacity, and screen and treat programs indicators.