This study examines ICT adoption among 3,759 Colombian manufacturing firms, and attemptsto identify the factors that are conducive to the adoption and usage of ICT at the firm level. Ourmajor findings are (i) that the adoption of a given information and communication technology isbetter facilitated when a firm is relatively large, has large human capital, engages in moreinnovative activities, and when a firm´s organizational structure is better aligned with the giventechnology; (ii) that positive associations between the key determinants and ICT adoptions aremore pronounced for small and medium-sized firms than for large ones, and (iii) that informationspillovers within industries is also a determinant of ICT adoptions by the firms.