The situation of compulsory confinement arises as a preventive measure against the COVID-19 pandemic, becoming a stressful event, in the face of which it was necessary to deploy coping strategies that would allow individuals to respond adaptively to the situation. The objective of this study was to know and compare the coping strategies deployed by people with a positive diagnosis for COVID-19 and relatives of people with a positive diagnosis for COVID-19, against the confinement carried out in the framework of the pandemic. Qualitative research of a phenomenological-hermeneutic type was carried out, using the semi-structured interview as a tool for investigating the confinement experience of four participants, working with two family nuclei, wherein each one, a person who had been diagnosed with COVID-19 and a family member of the person diagnosed with COVID-19. At first, the study of the information was done by participants, and later a comparison was made by dyads and family nuclei. In the results, it was evidenced that the four participants made use of coping strategies focused on emotion and focused on the problem, with the belief system being a determining factor when evaluating the stressful event as a threat, damage/loss, or challenge. allowing or hindering an adaptive response to it.