The main objective of this study was to carry out a systematic review of the literature regarding protocols, interventions and/or activities based on metacognitive skills or metacognition as an intervention strategy in people with different levels of cognitive disability or cognitive impairment. Twenty articles from the years 1998-2020 were reviewed and it was found that the development of intervention activities through metacognitive strategies in a population with cognitive impairment and cognitive disability improves cognitive, metacognitive, academic and social development processes; However, there is not a large body of publications on this subject, making it difficult to determine the effect that interventions based on metacognitive skills have on the performance in different areas of people diagnosed with cognitive disabilities or cognitive impairment