The Urban developments related to knowledge and innovation industries drive urban transformations in cities around the world; This growth of the cities strengthens the local economy and creates growth networks, commercial relationships, services etc. It´s have an impact at zonal, regional and national scales. In cases of intermediate cities such Duitama, Boyaca, the so-called innovation districts can be solutions for grouping new creative industries, but they can also potentiate areas such as education, culture, environment and, in this sense, promote local values in order to potentiate the culture of hand with innovation. The research problem arises from the following question: ? What habitability and urban development strategies can boost the economic growth of the central areas of the cities with processes in decline? Because the project addresses the problem from an area of the city that It is deteriorated and sees it as a development opportunity. The general objective of this work is to design a model of urban development, where first, the public space points to dynamics of coexistence among the inhabitants; and second, the work spaces help the economic development of new innovative ideas and entrepreneurship. The development of the project begins with the analysis of the city of Duitama, its regional and national impact and the search of the opportunities that the municipality offers from social, cultural and environmental issues. Problems are analyzed in the central urban area of the Vatican neighborhood to generate strategies that solve specific problems such as the recovery of heritage facilities, important road connections, environmental recovery and economic strengthening from local innovation; in addition to the relocation of existing homes in areas near the neighborhood, with declarations of. Invasion areas of non-mitigable risk.