This article analyzes the religious shift that has been taking place in Latin America, marked by a fall in the number of practicing Catholics, the growing strength of evangelical churches, and increasing secularization over the last thirty years. This shift prompts three separate reflections: on the marginalization of religion across the continent, on the crises within the Catholic Church in the wake of all the debates surrounding Vatican II and liberation theology, and on the internal world of evangelical churches. The article’s analysis shows the complexity of the religious world in present-day Latin America, a continent where religion has always been key to better understanding its dynamics and developments.