Mexico shows a low rate in organ donation, and the waiting list for a transplantation grows every year. Famlily consent represents a limiting factor for donating and there are specific barriers that can be identified to improve donation consent rates. To identify the attitudes and intentions from the relatives of hospitalized patients, towards the donation of organs and tissues. A cross-sectional study was conducted using a structured survey of 89 subjects at the Civil Hospital Antonio Gonzalez Guevara of Tepic, Nayarit. The survey was validated by experts from the State Centers for Organ and Tissue Transplantations of Jalisco and Nayarit. The data were subjected to descriptive analysis. The average age was 36.84 ± 12.55 years old, in 71% of the female sex. The predominant educational level was secondary school. 81% of the participants agreed with the donation; and over 80% of them, had technical or university education. 68.8% consider that in Mexico, information about the subject is provided, although 43% believe that the government benefits financially from the donation of organs and tissues. For the 83.15%, the donation is accepted as an act of solidarity. The internal consistency of the survey using the Cronbach alpha test reported a value of 0.725. Although there is a good attitude and intention towards the donation from the relatives of hospitalized patients, it is necessary family comunication, and to overcome the limitations imposed by misinformation and the imaginary about organ trafficking. Investing resources into these specific populations of potential organ donors, can help improve consent rates.