Ethnopharmacological importance: Medicinal plants have been used by humans since before the Neolithic period for the empirical treatment of many diseases and afflictions. This study documents the medicinal species used in home gardens of two rural neighborhood in Guaduas, Cundinamarca. Likewise, it identifies it's uses and categorical tendencies. Materials and methods: Semistructured direct interviews to 30 residents of the rural neighborhoods Chipauta and Granada were made. Interviews were analyzed through three quantitative methods: a) the informant consensus index (ICF), b) the relative importance (RI) and c) the level of fidelity of the informants (FL). Results: 75 medicinal species were identified corresponding to 38 botanical families, which acts upon 14 human body systems. The most frequently named families were Compositae and Lamiaceae. ICF results showed that the categories with the greatest consensus of informants are the digestive, nervous and integumentary systems. According to RI the most versatile species are Aloe vera and Mentha x piperita. Talking about FL, Mentha x piperita is the most preferred plant to treat stomach pain, Cymbopogon citratus is the most used as an anti-flu and Aloe vera is the most used species for hair treatment. Conclusion: Relatively the same amount of native and introduced species was found. This study demonstrates the importance of medicinal plants for primary care of the study area in Guaduas. It is necessary to support ethnobotanical knowledge with pharmacological studies.