Introduction: in recent years, advances in noninvasive diagnostic methods, such as magnetic resonance imaging and computed tomography, have allowed the assessment of complex anatomical structures, which has prompted a growing interest in the evaluation of patients with suspected coronary artery disease. From a radiological point of view, assessment of the coronary arteries has presented many challenges, including the small size of the structures to be evaluated, the constant motion of the heart, and respiratory movements. Objective: to describe the imaging findings and the diagnostic usefulness of magnetic resonance imaging and computed tomography in patients with suspected coronary disease. Materials and methods: a descriptive case series on diagnosis of patients with suspected coronary artery disease in a high complexity diagnostic imaging center in Medellin, Colombia. Results: four patients with suspected coronary disease were analyzed. The first of the series, demonstrates the utility of computed tomography angiography for excluding coronary disease in a patient with intermediate risk and inconclusive stress test. The following two cases, demonstrate the usefulness of computed tomography and magnetic resonance imaging to evaluate the anatomical relationships in anomalous origin and course of the coronary arteries. Finally, a case of coronary arterial fistula and its assessment by magnetic resonance imaging is presented. Conclusion: computed tomography angiography and magnetic resonance imaging have become useful noninvasive diagnostic tools for the detection of coronary artery disease. Currently, these techniques are considered the gold standard in cases of anatomical abnormalities of the origin and course of the coronary arteries, and every day they play a greater role in the exclusion of atherosclerotic disease, a major cause of mortality in developed countries.