The study, the incidence of public policy for the overcoming of poverty within the framework of the local economic development in Cartagena – Bolivar during the period 1994-2014, seeks to understand as it has been the interaction of the public policy of the national agenda with the departmental and municipal order, and as these have favored the inclusion of the population in poverty and vulnerability to the production system. The District of Cartagena de Indias, during the analysis period has shown a remarkable economic development; However, it is one of the capital cities with the highest incidence of poverty and extreme poverty; It is like since 2008, implemented the policy of productive Inclusion for the overcoming of the extreme poverty, which have been articulated different institutions in lathe of Local Economic Development and entailment of the vulnerable population into the productive system by means of entrepreneurship or employability, becoming a benchmark at national level.