Organizations dedicated to pest control, are characterized by being mostly small companies classified with high occupational risk due to the use of pesticides during their economic activity, for this reason they must adequately manage the health risks of workers. The present study is an intervention research; whose objective was to establish the process of pesticide management in a company dedicated to pest control in Cartagena de Indias, in order to reduce the health risk of personnel exposed to these substances. 100% was achieved in structuring the pesticide management system. In the implementation of the system it was reached between 84 to 100%. However, in the final evaluation, between 95 and 100% compliance was obtained. In relation to the results obtained in the health of workers, a decrease in the percentage of cholinesterase enzyme inhibition was observed, going from 30 to 13 and finally to 1.2% during the years 2016, 2017 and 2018, respectively. It concludes that with the implementation of the pesticide management system, continuous improvement of the organization and self-care by all the employees of the organization were promoted.