Mipres is a web application created in December 2016 by the Ministry of Health and Social Protection of Colombia to authorize the prescription of biomedical technologies not included in the Health Benefits Plan such as: medicines, devices, procedures, services, and nutritional products. Mipres emerges as the solution both of these technologies access restrictions and the uncontrollable increase in health spending. The thesis developed a critical analysis grounded on Critical Health Information Systems perspectives and Science and Technology Studies, which problematizes the idea that Mipres is an indisputable ‘solution’ and unfortunately it may be producing an important series of problems. I conducted a multi-sited device ethnography of the Mipres as a socio-material artifact from a critical reading in public health. This hoped to serve as a reflection and alternative way to uncritical digitizing phenomena and their effects on human health and life. Until December 2019, more than 15 million prescriptions have been made by Mipres to more than ten million people affiliated to the contributory regime, with an estimated cost that could mean between four and five billion pesos in recoveries for the State in 2020. Mipres has ended up becoming a window of opportunity for the Ministry of health to modify Colombia’s information infrastructure, achieving the digital penetration of the government in the health care institutions (hospitals and insurance companies), through a certain kinds of algorithmic governance. Mipres emphasis has been on exercise a centralized and distant digital regulation in health based on data, believing that this would be part of the solution to the structural problems of the system and, incidentally, paving the way for the emergence of complex bureaucratic data-processes that transfer the financial, administrative and health pressure to the health-providing institutions (hospitals, clinics, outpatient and home services), disturbing the exercise of medical practice and the health of patients. Mipres became a digital platform that, due to the technological ingenuity of its design process, nurtured and amplified new financial responses, pressures from the biomedical industry, limited doctors’ autonomy, etc. Mipres digital adjustments change Colombian health system step by step without transforming the structural conditions that perpetuate its financial emphasis and systematic violence against people, imposing new technological and data barriers to access and provision of health services that affected and endangered people’s lives.