Religion and psychology have tried to explain the existence of man and his conduct, and to give meaning to it, each from its own point of view, religion being a doctrine of spirituality, faith and hope, around a supreme being, and psychology studying the mind, human conduct and mental processes. Man is an individual composed of subjectivity, emotionality, culture, etc. And therefore of deficiencies and suffering, motivated to fill these deficiencies and stop suffering; humanist theory, more precisely Abraham Maslow with the theory of the hierarchy of needs, explains how human behavior is governed by needs and the motivation to satisfy them; on the other hand the concept of suffering goes from physical pain to emotional distress, and in this case is limited to that lack of, which motivates man to satisfy his needs. This monographic work is a comparative study between religion and psychotherapy, whose general objective is to explain the need to assign meaning to human suffering from these two disciplines, and has as specific objectives, to argue, interpret and define, in three chapters, the social, moral and ethical responsibility to assign meaning to human suffering from religion and psychotherapy. The intention is to approach this topic within the framework of our society, and to offer a vision as objective as possible to those who feel attracted or interested by this type of studies.