Introduction: The genus Salmonella is comprised by facultative anaerobic Gram-negative rods, glucose fermenters, and positives to citrate; negatives to oxidase, lactose, sucrose, urea and indole, are mobile and produce sulfur (except Salmonella enterica serotype Typhi). Infection for non-typhoid Salmonella occurs by ingesting food or water contaminated with feces from humans or animals as reptiles and amphibians. Aim: To detect the presence of Salmonella spp. in samples of reptiles, amphibians and birds that live with children less than 12 years and establishing antimicrobial susceptibility of isolates. Materials and Methods: Stool samples of 50 animals (reptiles, amphibians and birds) were collected in Bogota D.C. and six municipalities in Cundinamarca, Colombia. The exotic animals recorded during samples collection were communicated to Secretaria del Medio Ambiente and Corporacion Autonoma Regional (CAR) Cundinamarca. The samples were processed in Rappaport–Vassiliadis and MacConkey agar at 37 °C for 24 h, then we performed biochemical tests, agglutination and antimicrobial susceptibility for 11 antibiotics commonly used in the treatment of Salmonella spp. infection. Results: From stool samples of 14 amphibians, six reptiles, 30 birds and one child, we identify 29 (58%) Salmonella spp. isolates, corresponding to 11 amphibians (78,6%), four reptiles (66,6%) and 14 birds (50%). Five isolates were identified as Salmonella enterica subsp. arizonae. Between a 34% and 94% of rate of antibiotic resistance were find. Conclusion: The presence of Salmonella enterica in exotic animals that live with children less than 12 years, and the high in vitro resistance to antibiotics tested, is a serious public health problem that posed the implementation of preventive measures in the care of these animals.