Background: Syphilis is a sexually transmitted disease caused by Treponema pallidum. It can remain dormant in the individual throughout life. The manifestations of ocular involvement are similar to other infl ammatory eye conditions. It is crucial to make an early diagnosis and management in order to avoid complication.Objective: to describe the clinical characteristics and the results of the treatment of patients with ocular syphilis.Study design: observational retrospective studyMethod: Retrospective cohort of patients with ocular syphilis evaluated in an ophthalmology reference center in Colombia from March 2015 to February 2017.Results: Sixteen patients were diagnosed with ocular syphilis during the studied period. Four (25%) patients had involvement of both eyes, for a total of 20 eyes. Th ere were 11 (68.8%) men and 5 (31.3%) women. The mean age of presentation was 51.1 years (23-86 years). Four male patients were coinfected with HIV. The most frequent manifestation was panuveitis in eight eyes (40%). Six patients (37.5%) presented systemic dermatological findings. Treatment included crystalline penicillin and systemic steroids. Th e mean follow-up was 16.2 months (12-21 months). Th e mean visual acuity improved from 1.01 ± 0.71 logMAR to 0.58 ± 0.64 logMAR after treatment.Conclusion: Syphilis is a rare cause of intraocular inflammation. However, the incidence has been increasing in recent years in both HIV positive and HIV negative patients. Panuveitis is the most frequent ocular fi nding. The visual prognosis is good if there is an early diagnosis and treatment.