The objective of the present work was to evaluate 12 sugarcane cultivars in irrigation and no irrigation conditions in the agroclimatic zone of the Mayabeque province for their possible introduction in sugarcane production. The study was carried out in the experimental block of the Sugarcane Territorial Research Station (ETICA). The plantation was done in the cold season and two crops were made, one in cane plant (18 months old) and another in the first offspring (13 months old) in a typical Red Ferralitic soil, the variables evaluated were tons of cane per hectare (TCH) and tons of pol per hectare (TPH). During the period of cane plant, 27 irrigations were applied 9450 m3 ha-1 total net duty, while in the first shoot only 14 irrigations were applied and 4900 m3 ha-1 total net duty. Highly significant differences between irrigation and no irrigation were observed for the two variables analyzed and irrigation increased yield in TCH and TPH by more than 25%. The varieties C92-325, C86-12, C86-156 and C120-78 reached yields higher than 230 t ha-1 when considering the total TCH in the entire period studied and differed significantly from the rest, the first two with differences of more than 100 t ha-1 with respect to the C86-165 variety of lower yield. The best response cultivars in TCH and TPH under irrigation during the two periods studied were C92-325, C86-12, C86-156 and C120-78, with a cost-benefit ratio greater than 1,13.