Objective: The purpose of this work is to cross link PVA with glutaraldehyde to develop new films with increased waterproof properties. Methods: Cross linking of PVA with glutaraldehyde was conducted at 70°C at a 1:10 and 1:5 PVA: glutaraldehyde ratios. pH and reaction times of 5.5 and 6.5 and 1 and 6h were employed, respectively. The resulting films were analyzed for Cross linking degree, crystallinity, water sorption, swelling, contact angle, and tablet water uptake when stored for 45 days at 100% relative humidity. Results: Reactions conducted at a pH of 5.5 rendered the largest Cross linking degrees. Cross linked films were less crystalline, flexible and hydrophilic. Further, they had a lower ability to swell and uptake water than the parent PVA. Moreover, compacts stored for 45 days and coated with cross linked films had a low water sorption ability than those coated with non-crosslinked PVA. Conclusion: Cross linking of PVA with glutaraldehyde rendered films with a tight polymeric network, a reduced hydrogen bonding capacity, more hydrophobicity, and better waterproof properties in compacts containing hydro labile drugs.