The purpose of this paper is to analyze the role of the law against the regulation of assisted human reproduction and surrogacy in Colombia. In this sense, three specific objectives were formulated, namely: 1.- To study the aspects to be considered in the legal regulation of assisted human reproduction and surrogate motherhood; 2.- Analyze the jurisprudence regarding assisted human reproduction and surrogate motherhood; and 3.- Determine the legal challenges of Colombian legislation to regulate the techniques of assisted human reproduction - surrogate motherhood. It was a basic legal investigation, since it is about describing the phenomenon, in which the hermeneutic method was used since the object of study was interpreted from the right. The doctrine coincides in nullifying surrogacy contracts as being contrary to public order, morality and good manners; nevertheless, it is a phenomenon that has escaped the legislator's control and that despite the exhortation and orders of the Constitutional Court, even in Colombia the lack of a rule that regulates it together with the scientific techniques of assisted human reproduction persists. Consequently, its purpose is outside of commerce, unfolds motherhood, alters marital status and reifies the child.