After several researches on architecture from an aesthetic perspective, it is evident that the classic models of urban planning do not give a response to habitat and habitability, so this theoretical-experimental work focuses on investigating new forms of studies And projections of the biocomputational architecture under a transversal heuristic methodology of bioinformatic modeling and simulations, projecting a symbiosis with evolutionary biodiverse ecosystems, artificial life and habitat. For the development of this work it was chosen the Wetland, Santa Maria del Lago, being a complex ecosystem within the city, which presents multiple variables and interactions to be investigated. Firstly, a description and location of the case study and the problem are presented. The phenomenon of impacts on the ecosystem of the wetland is investigated through urbanization, until it reaches the point of its deterioration and the problem is evidenced. Consecutively the components of the wetland ecosystem are investigated as diverse variables to be implemented in the simulation proposal. In the epistemological theoretical framework the concepts of biology and bioinformatics on carbon and artificial life are investigated, together with the blue economy and how they can be implemented. The heuristic methodology is deployed through transversal simulations, based on life strategies such as self-organization, to reach the proposal, which emerges through the interaction of the species of an artificial ecosystem, based on swarm intelligence.