Antecedentes : La calidad de vida (CV) relacionada con la salud es un indicador de desempeno de los sistemas sanitarios; no obstante, se desconoce su estado en personas con diabetes tipo 2, lo que limita la implementacion y evaluacion de intervenciones dirigidas a mejorar su salud. Objetivo : Identificar los dominios mas afectados en la CV de pacientes con diabetes tipo 2. Metodo : Busqueda sistematica en las bases de datos LILACS, Pubmed, Embase y Google Academico, de estudios observacionales que midieron de manera cuantitativa la CV de pacientes con diabetes tipo 2, sin importar la comorbilidad o estado funcional, en el contexto ambulatorio u hospitalario en Colombia. Para identificar los dominios mas afectados se realizo un metaanalisis acumulativo de estudios observacionales que midieron la CV con los Cuestionarios de Salud SF-36 (Short Form-36) y SF-8 (Short Form-8), y se realizo un modelo de efectos aleatorios que permitio la estimacion de las medias como medida de efecto combinado. Resultados : Se identificaron siete articulos, de los cuales cuatro fueron incluidos en la sintesis cuantitativa. Los dominios de la CV de los pacientes con diabetes tipo 2 mas afectados segun los Cuestionarios SF-36 y SF-8 fueron salud general 49,7 (IC 95%: 37,3 a 62,0), rol fisico 53,6 (IC 95%: 35,6 a 71,6) y funcion fisica 53,8 (IC 95%: 34,8 a 72,8). Conclusion : Los programas preventivos y de atencion a personas con diabetes tipo 2 deben enfocarse en un manejo integral que contribuya al mejoramiento de su CV relacionada con su salud. Palabras claves: Calidad de vida, Diabetes tipo 2, Enfermedades cronicas, Cuidado de salud, Colombia, Revision sistematica, Metaanalisis acumulativo. Abstract Background : The quality of life related to health is an indicator performance of health system; however, its condition in people with type 2 diabetes is unknown, which limits the implementation and evaluation of interventions aimed at improving their health. Objectives : to identify the most affected domains in the quality of life in people with 2 type diabetes. Methods : systematic search in LILACS, Pubmed, Embase and Google Scholar data bases for observational studies that measure quantitatively the quality of life for patients with diabetes type 2, despite comorbidity or functional status, in the ambulatory or hospital setting in Colombia. In order to identify the most affected domains, it was carried out a cumulative meta-analysis of observational studies aimed to measure life quality through the Health Questionnaires SF-36 (Short Form-36) and SF-8 (Short Form-8), and also, a Random effects model was conducted, which allowed the average as a measure of combined effect. Results : seven articles were identified, of which four were included in the quantitative synthesis, the most affected domains according to SF-36 and SF-8 were general health 49.7 (95% CI: 37.3 to 62.0), physical role 53.6 (95% CI: 35.6 to 71.6), physical function 53.8 (95% CI: 34.8 to 72.8). Conclusion : Preventive and care programs for people with type 2 diabetes should focus on comprehensive management that contributes to quality of life improvement concerned health. It is still required to expand the investigation to account for the results in people's health. Key words: Quality of Life, Type 2 Diabetes, Chronic Diseases, Health Care, Colombia, Meta-analysis, Review.