This research reports and reflects from the anthropological perspective the experience of patients with Chronic Renal Disease (CKD) in the current Colombian health system, describing the complex itineraries to which they are subjected under the bureaucracies that constitute the General Social Security System in Health (SGSSS). Based on the experience reported by four patients treated at the Renal Foundation of Colombia (FRC), Zipaquira. A phenomenological approach is built, contrasted with a documentary review that allows us to talk about the disease-health-attention trinomial. It is important to mention the experience of the disease as a social construction mediated by economic and social factors, as reflected in the affiliation regimes to which people in the Colombian health system are subject. This research also seeks to present the experience of people in the contributory and subsidized regime facing a high-cost illness such as CKD. This research describes some difficulties that the system has not only at the level of application and comprehensive care, but also in the ways of access to information that citizens have and the few strategies to present patients clearly and concretely guarantees and duties they have. Finally, it is intended to draw attention to the importance of risk factors and population conditions, including high unemployment rates, inequality in services according to economic income, geographic location and other factors that are considered vital for guarantee access to health.