Background: Fuchs heterochromic iridocyclitis (FHI) represents 2 to 7% of cases of anterior uveitis.To date, few studies have addressed corneal astigmatism as an inherent condition and as possible cause of decreased visual acuity in FHI patients. This may be relevant since the generated anisometropia may lead to alterations in visual acuity.Objective: To evaluate the presence of corneal astigmatism and/or corneal aberrations in patients with FHI.Method: A convenient sampling was performed. The sample included 44 eyes of 22 patients with unilateral or bilateral FHI. All participants were studied by corneal tomography (Pentacam® AXL – OCULUS) and aberrometry (OPD-Scan III® - NIDEK); measurements of diseased and healthy eyes were compared.Results: Twenty-two patients were enrolled in this study. The mean age at diagnosis was 46.9 +/- 12 years, and 40.9% were men. FHI eyes exhibited a median astigmatism of the anterior surface of 1.35D (IQR: 0.50 – 1.70), compared to 0.8D (IQR: 0.7 – 1.1) observed in healthy eyes (p= 0.135). Anterior surface astigmatism >1.00 diopters (D) was found in 61.5% of diseased eyes compared to 27.8% of healthy eyes, with a risk ratio of 2.15. Regarding corneal aberrations, no statistically significant differences were identified between diseased and healthy eyes for the analyzed aberrations. Conclusion: While our current data does not show statistically significant differences between groups that support that corneal astigmatism or aberrations are inherent to FHI-affected eyes, our study does show a trend that suggests increased presence of clinically relevant astigmatism in eyes with FHI. Statistical significance may be achieved with a larger sample size.